By considering the problems that commercial saffron companies have faced in international markets, the aim of this study is to investigate the impact of website content, including informational and design dimensions, on the effectiveness of e-marketing and e-trust as mediator variables. These aspects are examined with reference to sales and marketing division managers in a sample of 100 commercial saffron corporations in the Khorasan province. The findings support the ideas that website content has an effect on e-marketing and e-trust and that e-trust plays a mediating role in the relationship between e-trust and e-marketing effectiveness.